Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
Background: The present study aimed to expound the association between the XK related 6 gene (XKR6)\nrs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles and the risk of coronary artery disease\n(CAD) and ischemic stroke.\nMethods: The genetic makeup of the XKR6 rs7819412 SNP in 1783 unrelated participants (controls, 643; CAD, 588\nand ischemic stroke, 552) of Han Chinese was obtained by the Snapshot technology.\nResults: The genotypic frequencies of the SNP were disparate between CAD (GG, 81.0%; GA/AA, 19.0%) or ischemic\nstroke (GG, 81.2%; GA/AA, 18.8%) patients and healthy controls (GG, 85.7%, GA/AA, 14.3%; P < 0.05 vs. CAD or ischemic\nstroke; respectively). The A allele frequency was also diverse between CAD (10.1%) or ischemic stroke (10.0%) and\ncontrol groups (7.5%; P < 0.05 vs. CAD or ischemic stroke; respectively). The GA/AA genotypes and A allele were\nassociated with high risk of CAD and ischemic stroke (CAD: P = 0.026 for GA/AA vs. GG, P = 0.024 for A vs. G; Ischemic\nstroke: P = 0.029 for GA/AA vs. GG, P = 0.036 for A vs. G). The GA/AA genotypes were also associated with increased\nserum triglyceride (TG) concentration in CAD and total cholesterol (TC) concentration in ischemic stroke patients.\nConclusions: These data revealed that the XKR6 rs7819412 A allele was related to increased serum TG levels in CAD,\nTC levels in ischemic stroke patients and high risk of CAD and ischemic stroke....
Background: Heart failure (HF) with mid-range ejection fraction (EF) (HFmrEF) has attracted increasing attention in\nrecent years. However, the understanding of HFmrEF remains limited, especially among Asian patients. Therefore,\nanalysis of a Chinese HF registry was undertaken to explore the clinical characteristics and prognosis of HFmrEF.\nMethods: A total of 755 HF patients from a multi-centre registry were classified into three groups based on EF\nmeasured by echocardiogram at recruitment: HF with reduced EF (HFrEF) (n = 211), HFmrEF (n = 201), and HF with\npreserved EF (HFpEF) (n = 343). Clinical data were carefully collected and analyzed at baseline. The primary endpoint\nwas all-cause mortality and cardiovascular mortality while the secondary endpoints included hospitalization due to\nHF and major adverse cardiac events (MACE) during 1-year follow-up. Cox regression and Logistic regression were\nperformed to identify the association between the three EF strata and 1-year outcomes.\nResults: The prevalence of HFmrEF was 26.6% in the observed HF patients. Most of the clinical characteristics of\nHFmrEF were intermediate between HFrEF and HFpEF. But a significantly higher ratio of prior myocardial\ninfarction (p = 0.002), ischemic heart disease etiology (p = 0.004), antiplatelet drug use (p = 0.009), angioplasty\nor stent implantation (p = 0.003) were observed in patients with HFmrEF patients than those with HFpEF and\nHFrEF. Multivariate analysis showed that the HFmrEF group presented a better prognosis than HFrEF in all-cause\nmortality [p = 0.022, HR (95%CI): 0.473(0.215-0.887)], cardiovascular mortality [p = 0.005, HR (95%CI): 0.270(0.108-0.672)]\nand MACE [p = 0.034, OR (95%CI): 0.450(0.215-0.941)] at 1 year. However, no significant differences in 1-year outcomes\nwere observed between HFmrEF and HFpEF.\nConclusion: HFmrEF is a distinctive subgroup of HF. The strikingly prevalence of ischemic history among patients with\nHFmrEF might indicate a key to profound understanding of HFmrEF. Patients in HFmrEF group presented better 1-year\noutcomes than HFrEF group. The long-term prognosis and optimal medications for HFmrEF require further\ninvestigations....
Background: This study examines how prevalence and clustering of cardiovascular disease (CVD) risk factors differ\nby ethnicity and socioeconomic status (SES) among rural southwest Chinese adults.\nMethods: A cross-sectional survey of 7027 adults aged greater than equal to35 years of Han and four ethnic minority group descent\n(Na Xi, Li Shu, Dai, and Jing Po) was used to derive prevalence of tobacco smoking and exposure to secondhand\nsmoke (SHS) as well as alcohol consumption and physical activity data. Anthropometric measurements were also\ntaken, including height, weight, and waist and hip circumference, as well as blood pressure (BP) and fasting blood\nglucose (FBG) measurements.\nResults: Current smoking and drinking status were the top two CVD risk factors in the study population. Dai ethnic\nminority participants had the highest prevalence of hypertension, obesity, and central obesity, whereas Jing Po\nethnic minority participants had the highest prevalence of current smoking status, SHS exposure, and current\ndrinking status (P < 0.01). Han participants had the highest prevalence of diabetes and physical inactivity (P < 0.01).\n11.1% of all participants did not have any of the studied CVD risk factors, while 68.6% of Han, 60.2% of Na Xi, 50.7%\nof Li Shu, 82.2% of Dai, and 73.0% of Jing Po participants had clustering of two or more CVD risk factors. Prevalence\nof CVD risk factor clusters increased with age (P < 0.01). Males and individuals with lower education levels and lower\nannual household income were more likely to have CVD risk factors than their counterparts (P < 0.01).\nConclusion: Clustering of CVD risk factors is common in rural southwest China. Ethnicity and individual SES\nsignificantly impact prevalence of CVD risk factors and their clustering....
Background: Mineralocorticoid receptor antagonists (MRA) are an underutilized therapy for heart failure with a reduced\nejection fraction (HFrEF), but the current impact of hospitalization on MRA use is not well characterized. The objective of\nthis study was to describe contemporary MRA prescription for heart failure patients before and after the full scope of\nhospitalizations and the association between MRA discharge prescription and post-hospitalization outcomes.\nMethods: We conducted a retrospective cohort study at an academic hospital system in 2013-2016. Among 1500\nincluded hospitalizations of 1009 unique patients with HFrEF and without MRA contraindication, the mean age was...................
Background: With the improved lifestyle of people, the incidence of coronary\nartery disease is gradually increasing. Approximately 15% - 20% of patients\nundergoing diagnostic catheterization had one or more chronically occluded\ncoronary arteries. Method: The patients who were diagnosed with chronic\ntotal occlusion (CTO) in our hospital within one year period have been included.\nThey were initially divided into two groups based on angiographic\nreports: single vessel disease (SVD) and non-single vessel disease (non-SVD)\ngroup, then into optimal medical therapy (OMT) group, percutaneous coronary\nintervention (PCI) group and coronary artery bypass graft (CABG) group.\nFinally, PCI group is further divided into PCI of CTO lesion (CTO PCI group)\nand PCI of non-CTO lesion (non-CTO PCI group). Results: A total of 261 patients\nwere enrolled as CTO patients, mean age was 62.83 years, 70.1% were\nmale patients. The incidence rate of common risk factors was hypertension\n(64.4%), followed by smoking (48.3%), diabetes (34.5%) and hyperlipidaemia\n(27.2%). SVD, DVD and TVD were present in 39 patients (14.94%), 81 patients\n(31.03%) and 141 patients (54.02%) respectively. Comparing the long term efficacy,\nthe rates of MACE and non-target vessel revascularization were higher\nin CTO PCI than non-CTO PCI group, and were statistically significant (p <\n0.05). The rates of target vessel revascularization, CABG and all cause death\nwere also lower in CTO PCI group, but were not statistically significant (p >\n0.05). Conclusion: The rates of MACE, non-target vessel revascularization,\nCABG and all cause death are lower if PCI is successfully performed in CTO\npatients. CTO PCI success also improves quality of life, decreases myocardial\nischemia induced angina, and overall improves long term efficacy....
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